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The Photoconductive Stimulation Device
The Photoconductive Stimulation Device enables neuroscience researchers and pharmaceutical technicians to depolarize dissociated neurons non-invasively and in a highly targeted manner.
Highlights
- Non-invasive electrical stimulation can be done without causing
damage to the cells
- Enables optical targeting of specific neurons to be depolarized
- Allows for the controlled variation of frequency and duration of
stimulation
- Short or long term non-invasive cell specific stimulation
- A replacement for pharmacological agonist stimulation (KCL), which
do not allow for targeting and repetitive depolarization
- The depolarization of a user-defined area of a dissociated culture,
not just those cells positioned on an electrode
- A means for increasing the flexibility of protocol design by having
more control over which cells are depolarized and when
- For controlled cell stimulation in combination with voltage
sensitive dyes
- Depolarize cells with specific patterns of excitation, which allows
for detailed investigation of excitable cells over time
- Significantly reduces the time and skill level required to obtain
excitation, in that electrophysiology techniques and equipment are not
required
Example Uses
- Ion channel analysis
- Long term potentiation in the presence of specific controlled brain
activity
- Depolarize cells in the presence of pharmaceutical compounds to
screen for efficacy
- Long term analysis of cultures undergoing controlled depolarization
- Can be used with any excitable cells, including those from the
hippocampus, cortex and striatum
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