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The Photoconductive Stimulation Device

The Photoconductive Stimulation Device enables neuroscience researchers and pharmaceutical technicians to depolarize dissociated neurons non-invasively and in a highly targeted manner.





Highlights
  • Non-invasive electrical stimulation can be done without causing damage to the cells

  • Enables optical targeting of specific neurons to be depolarized

  • Allows for the controlled variation of frequency and duration of stimulation

  • Short or long term non-invasive cell specific stimulation

  • A replacement for pharmacological agonist stimulation (KCL), which do not allow for targeting and repetitive depolarization

  • The depolarization of a user-defined area of a dissociated culture, not just those cells positioned on an electrode

  • A means for increasing the flexibility of protocol design by having more control over which cells are depolarized and when

  • For controlled cell stimulation in combination with voltage sensitive dyes

  • Depolarize cells with specific patterns of excitation, which allows for detailed investigation of excitable cells over time

  • Significantly reduces the time and skill level required to obtain excitation, in that electrophysiology techniques and equipment are not required

Example Uses
  • Ion channel analysis

  • Long term potentiation in the presence of specific controlled brain activity

  • Depolarize cells in the presence of pharmaceutical compounds to screen for efficacy

  • Long term analysis of cultures undergoing controlled depolarization

  • Can be used with any excitable cells, including those from the hippocampus, cortex and striatum

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